122 articles - From Friday Feb 28 2025 to Friday Mar 07 2025
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
| Am J Gastroenterol |
|---|
Optimizing Bowel Preparation Quality for Colonoscopy: Consensus Recommendations by the US Multi-Society Task Force on Colorectal Cancer. We suggest the adjunctive use of oral simethicone for bowel preparation before colonoscopy. Routine tracking of the rate of adequate bowel preparations at the level of individual endoscopists and at the level of the endoscopy unit is also recommended, with a target of >90% for both rates. |
| Gastroenterology |
Optimizing Bowel Preparation Quality for Colonoscopy: Consensus Recommendations by the US Multi-Society Task Force on Colorectal Cancer. We suggest the adjunctive use of oral simethicone for bowel preparation before colonoscopy. Routine tracking of the rate of adequate bowel preparations at the level of individual endoscopists and at the level of the endoscopy unit is also recommended, with a target of >90% for both rates. |
| Gastrointest Endosc |
Impact of EUS-guided fine-needle biopsy on International Consensus Diagnostic Criteria for diagnosing autoimmune pancreatitis: a prospective multicenter study. EUS-FNB using end-cutting needles enhances ICDC criteria in >90% of patients, ruling out malignancy in focal presentations and defining the specific subtype of AIP. Clinicaltrial gov number, NCT04397731. |
Optimizing bowel preparation quality for colonoscopy: consensus recommendations by the US Multi-Society Task Force on Colorectal Cancer. We suggest the adjunctive use of oral simethicone for bowel preparation before colonoscopy. Routine tracking of the rate of adequate bowel preparations at the level of individual endoscopists and at the level of the endoscopy unit is also recommended, with a target of >90% for both rates. |
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
|---|
| Am J Gastroenterol |
Accuracy of Visual Estimation for Measuring Colonic Polyp Size: A Systematic Review and Meta-Analysis. Visual estimation is an inaccurate and imprecise way to measure colorectal polyps. Further research is needed to determine the impact on clinical outcomes related to colorectal cancer. Investment in new technology to aid in polyp measurement is an important next step. |
Safety and Efficacy of Cold compared to Hot Endoscopic Mucosal Resection of Large Non-Pedunculated Colorectal Polyps: Systematic Review and Meta-Analysis. Four additional cohort studies were included in the secondary analyses. On random effects modeling, c-EMR was associated with a significantly lower risk of delayed bleeding (OR, 0.25 [95%CI:0.11 - 0.57], p=0.001, I2 =0%), early bleeding (OR, 0.34 [95%: 0.2 - 0.6], p 20 mm in size, but strategies to manage the higher odds of recurrence remain essential. |
| Gastrointest Endosc |
Outcomes of Interval Cholecystectomy Following Endoscopic Ultrasound-guided Gallbladder Drainage: A Systematic Review and Meta-Analysis. Our study demonstrates that interval CCY is technically feasible and safe after EUS-GBD. Endoscopists should still consider the local surgical expertise and recommendations before performing EUS-GBD in patients who could eventually become surgical candidates afterward. |
| Gut |
Glucagon-like peptide-1 receptor agonist use is associated with a lower risk of major adverse liver-related outcomes: a meta-analysis of observational cohort studies. GLP-1RA use is associated with a lower risk of liver-related complications and hepatic decompensation in people with T2D. These findings suggest a role of GLP-1RAs in preventing liver-related complications beyond their beneficial cardiometabolic effects. |
RCT, clinical trials, retrospective studies, etc…
| Aliment Pharmacol Ther |
|---|
Differential Characteristics and Survival Outcomes of Patients With Cirrhosis According to Underlying Liver Aetiology. Survival outcomes in patients with cirrhosis varied by aetiology and have changed over time, which should be taken into account for future practice guidelines and modelling studies. |
Effectiveness and Safety of Upadacitinib Induction Therapy for 223 Patients With Crohn's Disease: A GETAID Multicentre Cohort Study. In this real-world cohort of highly refractory CD patients, upadacitinib induction resulted in a clinical response in about two-thirds of patients and in SFCR in half of the patients, with an acceptable safety profile. |
Safety of Advanced Combination Treatment With Selective JAK1 Inhibitors and Biological Therapies in Inflammatory Bowel Diseases: A Real World Experience. The infection incidence rate was 25.4 per 100 person-years (95% CI: 6.47-69.19), though the wide confidence interval limits conclusions on safety differences with monotherapy. These findings highlight the importance of preventive measures, careful patient selection, and rigorous monitoring to mitigate infection risks associated with ACT. |
Women's Health Disorders in a Coeliac Disease Population After Diagnosis-A Nationwide Cohort Analysis. Women with coeliac disease have higher frequencies of subsequent women's health disorders related to ovarian function, menstruation, fertility and menopause. Clinicians should be aware of these associations to detect women's health disorders during longitudinal coeliac care and promptly refer for a multidisciplinary approach with obstetrics and gynaecology. |
| Am J Gastroenterol |
An unrecognized threat: An evaluation of exposure to air pollutants during smoke-generating endoscopy procedures. Smoke produced during endoscopy is a potential health risk for endoscopy staff. Protective measures and further research on long-term exposure effects are warranted. |
Anti-gliadin Antibodies and the Brain in People Without Celiac Disease: A Case-Control Study. Our analysis is the most comprehensive to date and uses a number of outcome measures known to be sensitive to subtle shifts in neurophysiology and cognition. Incidental AGA does not appear to be associated with any indications of neuropsychological deficit. |
Dry suction versus wet suction of endoscopic ultrasound-guided fine-needle biopsy for diagnosis of solid pancreatic lesions:a multicenter randomized controlled non-inferiority trial. regarding the suction techniques of EUS-FNB remain controversial. This study aimed to compare the diagnostic accuracy of the dry suction versus wet suction technique in solid pancreatic lesions (SPLs) and determine the optimal number of passes for EUS-FNB. Methods This investigation was conducted as a multicenter, randomized, controlled, non-inferiority trial. Patients with SPLs were randomly allocated to receive either the dry or wet suction technique. The primary outcome was diagnostic accuracy. The secondary outcomes included sensitivity, specificity, optimal number of needle passes, specimen quality, procedure time, and adverse events. Results Of the 200 patients, 193 were included in the final analysis, with 96 in the dry suction group and 97 in the wet suction group. The diagnostic accuracies were 97.92% and 96.91% in the dry and wet groups, respectively, with a 1.01% difference between the study groups (two-sided 95% CI, -3.47% to 5.48%, P=0.659). The overall adverse event rate was 2.6%. No significant differences were observed in sample adequacy (98.9% vs 98.9%, P = 1) or blood contamination (P = 0.796). Regarding procedure time, there was no statistical difference (18.68±8.03 min vs 19.36±8.89 min, P=0.626); however, more procedural steps were required in the wet suction technique. No significant difference was found between the cumulative diagnostic accuracy of each needle (1st pass 93.78% vs 2nd pass 95.34% vs 3rd pass 97.41%, P = 0.225). Disscussion The dry suction technique is non-inferior to the wet suction technique for EUS-FNB in SPLs. In the absence of rapid on-site evaluation (ROSE), only one pass was required to achieve more than 90% diagnostic accuracy. (ClinicalTrial.gov number NCT05549856.). |
Impact of Surveillance Colonoscopy Timing on Colorectal Cancer Incidence Following Advanced Adenoma Resection. In the AA group, surveillance colonoscopy within 3 years was associated with a lower risk of CRC. These findings suggest that a first surveillance within 3 years is particularly effective in patients with AA. |
Improving the Real-time Classification of Disease Severity in Ulcerative Colitis: Artificial Intelligence as the Trigger for a Second Opinion. Our innovative AI model shows significant potential for enhancing the accuracy of UC severity classification and improving the proficiency of non-IBD experts. It is designed for clinical use and has proven feasible in real-world testing. |
Increasing rate of hospitalization for inflammatory bowel disease is an age-related effect: A Canadian Population Study. These data support the hypothesis that age effects are primarily responsible for increased risk of hospitalizations. As the prevalence of IBD continues to rise and age distribution of Canadians shifts towards an older-aged population, increasing the allocation of healthcare resources to prevent age-related risks of hospitalizations would be beneficial to reduce hospital burdens. |
Neoplasia detection via colonic surveillance among young individuals with MSH6 and PMS2-associated Lynch Syndrome. Among individuals with MSH6/PMS2-associated LS undergoing early colonoscopy, neoplasia was common, even in those under 30. Current recommendations suggesting delayed initiation of surveillance among such patients may lead to missed preventive opportunities. |
| Clin Gastroenterol Hepatol |
Endoscopic En Bloc Versus Piecemeal Resection of Large Colonic Adenomas: carbon footprint post-hoc analysis of a randomized trial. ESD strategy for lesions over 25 mm could reduce the environmental impact by reducing the associated follow up colonoscopies and transports of patients. If P-EMR could be performed in local centers with similar quality, results would be in favor of local P-EMR. |
Gallbladder cancer and dysplasia in cholecystectomy specimens: A large study in high-incidence regions of South America. These recruitment-site specific risk factors may help refine current prevention strategies by prioritizing prophylactic cholecystectomy in high-risk patients. The approach used in this study may guide future investigations on GBC prevention in high-incidence, low-income regions. |
Liver decompensation in patients with hepatocellular carcinoma treated with Atezolizumab plus Bevacizumab: a real-life study. Atezobeva is effective in both Child Pugh A and B patients. The possibility to resume treatment after an episode of decompensation underscores the importance of integrated hepato-oncological management. |
Risks of 75 major congenital malformations after in utero exposure to thiopurines and anti-TNF for maternal inflammatory bowel disease. This study provides no evidence of substantial risk of MCM associated with in utero exposure to thiopurines or anti-TNF, except for talipes equinovarus, which appears increased with exposure to anti-TNF. This finding needs to be confirmed in further studies. |
| Endosc Int Open |
Endoscopic transpapillary gallbladder stenting vs percutaneous cholecystostomy for managing acute cholecystitis: Nationwide propensity score study. Our nationwide analysis revealed that ERCP-guided gallbladder drainage should be the preferred approach for managing acute cholecystitis when unfit for surgery. |
Hybrid percutaneous endoscopic gastrostomy (Hybrid PEG) improves patient safety by combining pull-through technique with gastropexy. Hybrid PEG and direct puncture are equally safe PEG insertion techniques, with significantly better safety profiles than the pull-through technique. Despite the retrospective design of the study, these results suggest preferential use of hybrid PEG due to handling. |
Improvement in adenoma detection rate by artificial intelligence-assisted colonoscopy: Multicenter quasi-randomized controlled trial. AI-assisted colonoscopy significantly increased ADR by 12.5% overall, with a notable 16.3% increase in the screening population. The unchanged NNRR indicates that the higher PDR was due to increased ADR, not unnecessary resections. |
Pediatric cylindrical battery ingestion. According to our study data, conservative management may be advised for the majority of cases of CB ingestion. However, we acknowledge that CB should be timely removed whenever they are A23 or A27 type, damaged prior to ingestion, in cases of multiple ingestion, whenever retained in the stomach for a prolonged period, or whenever a child complains about any clinical signs or symptoms or had undergone prior abdominal surgery. |
Real-world effectiveness and safety of 1L polyethylene glycol and ascorbic acid for bowel preparation in patients aged 80 years or older. This post-hoc analysis confirms 1L PEG-ASC to be an effective and safe bowel cleansing preparation for patients aged 80 years or older in a real-world setting. |
Sustained success in endoscopic performance demonstrated by the Irish National Endoscopy Quality Improvement Programme. This study represents the first published endoscopist-level NEQI data demonstrating ongoing KQI improvements for endoscopists at al activity levels. Sustaining this improvement and continuing to capture national endoscopic performance will remain a core role of the Irish NEQI program. Workforce imbalances and minimum annual volumes continue to represent challenges for national endoscopy programs. |
| Endoscopy |
Endoscopic ultrasound-guided tissue sampling: European Society of Gastrointestinal Endoscopy (ESGE) Technical and Technology Review. MIAB could represent the first choice for smaller lesions (<20 mm) if proper expertise is available. ESGE does not recommend the use of antibiotic prophylaxis before EUS-guided tissue sampling of solid masses and EUS-FNA of pancreatic cystic lesions. |
| Gastroenterology |
Artificial Intelligence Applications in Image-Based Diagnosis of Early Esophageal and Gastric Neoplasms. In the future, AI promises substantial advancements in automated real-time endoscopic guidance, personalized risk assessment, and optimized biopsy decision-making. As it evolves, it would substantially impact not only early diagnosis and prognosis but also the cost-effectiveness of managing upper GI diseases, ultimately leading to improved patient outcomes and more efficient healthcare delivery. |
Diagnostic Accuracy of Timed Barium Esophagram for Achalasia. TBE can accurately identify achalasia/FLIP+ EGJOO when using multiple metrics in a classification tree model. This provides a simple, standardized approach to TBE interpretation that is superior to traditional single-metric methods. |
The impact of HBsAg reduction via siRNA treatment on natural and vaccine (BRII-179)-induced HBV-specific humoral and cellular immune responses. Moreover, the neutralizing ability of the anti-HBs positive sera was associated with HBsAg reduction. SiRNA-induced HBsAg reduction may contribute to the persistence and efficacy of the humoral arm of HBV-specific adaptive immunity in CHB participants receiving therapeutic vaccine BRII-179. |
| Gastrointest Endosc |
Comparison of graphical user interfaces for computer-aided detection in Barrett's neoplasia. Subjectively, 23 endoscopists preferred the heatmap and 14 the bounding box (p=0.04). Although endoscopists expressed a preference for the heatmap GUI, this was not associated with a statistical difference in performance outcomes. |
Endoscopic Suturing to Prevent Migration of Esophageal Fully Covered Self-Expanding Metal Stents: A Randomized Controlled Trial. These findings support the efficacy, safety, and cost-effectiveness of endoscopic suture fixation for preventing esophageal FC-SEMS migration. Further studies comparing endoscopic suturing and other stent fixation strategies are warranted. |
Open Zenker's Peroral Endoscopic Myotomy: Technical and Clinical Outcomes of a Novel Technique. OZ-POEM is a novel, feasible, and safe procedure with a short procedure time, eliminating the need for incision site closure. The incorporation of extensive mucosotomy is the likely reason behind the very low recurrence rate (3.8%); however, prospective comparative studies are necessary to support these findings. |
Revisiting the Starting Age of Colorectal Cancer Screening for Average-Risk Asian Population: a cost-effectiveness analysis. Initiating CRC screening at age 45 using FIT in Hong Kong was determined to be a well-balanced and cost-effective strategy. This approach demonstrated a cost advantage over starting screening at age 40 and resulted in more lives saved compared to screening at age 50. |
Risk factors for difficult endoscopic bowel dilatation of predominantly shorter and non - inflammatory strictures among patients with inflammatory bowel disease: Findings from a IBD tertiary centers in Poland and Czech Republic. Reduction of difficult EBD should be considered primarily in the context of their modifiable risk factors. Prospective studies with simultaneous evaluation of transmural healing are needed to truly assess whether VDZ treatment, immunosuppressive therapy and total parenteral nutrition reduce the risk of EBD. |
| Gut |
24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting TH17 pathogenicity and transdifferentiation. Background 24-Nor-ursodeoxycholic acid (NorUDCA) is a novel therapeutic bile acid for treating immune-mediated cholestatic liver diseases, such as primary sclerosing cholangitis (PSC). Objective Since PSC strongly associates with T helper-type-like 17 (T 17-mediated intestinal diseases and beyond. |
Bioprinting functional hepatocyte organoids derived from human chemically induced pluripotent stem cells to treat liver failure. Our bioprinted hepatic tissue model exhibits remarkable therapeutic efficacy for liver failure and holds great potential for clinical research in the field of liver regenerative medicine. |
E-twenty-six-specific sequence variant 5 (ETV5) facilitates hepatocellular carcinoma progression and metastasis through enhancing polymorphonuclear myeloid-derived suppressor cell (PMN-MDSC)-mediated immunosuppression. ETV5 facilitates HCC progression and metastasis by promoting the recruitment, infiltration and activation of PMN-MDSCs. Synergistic application of anti-S100A9 or TLR4/RAGE inhibitors with anti-PD-L1 therapy holds great promise as an effective combinational treatment strategy for ETV5-positive HCC. |
Margin thermal ablation eliminates size as a risk factor for recurrence after piecemeal endoscopic mucosal resection of large non-pedunculated colorectal polyps. MTA negates the effect of size on the incidence of recurrence after piecemeal endoscopic mucosal resection of colorectal polyps ≥40 mm. Australian Colonic Endoscopic Resection cohort (NCT01368289; NCT02000141). |
| Hepatology |
Determining safe washout period for immune checkpoint inhibitors prior to liver transplantation: An international retrospective cohort study. Our findings suggest that a washout period longer than 50 days for ICIs before liver transplantation appears to be safe with respect to rejection risk. While these results may help guide clinical decision-making, future prospective studies are essential to establish definitive guidelines. |
| J Hepatol |
Circadian Control of Hepatic Ischemia/Reperfusion Injury via HSD17B13-Mediated Autophagy in Hepatocytes. The findings have scientific implications as they enhance our understanding of the circadian regulation of hepatic ischemia/reperfusion injury. Furthermore, clinically, this research offers opportunities for optimizing treatment strategies in hepatic ischemia/reperfusion injury by considering the timing of therapeutic interventions. |
Rat hepatitis E virus as an aetiological agent of acute hepatitis of unknown origin. Our study demonstrated that ratHEV is an emerging and underdiagnosed cause of acute hepatitis. The results provide evidence that ratHEV should be monitored and included in the differential diagnosis of acute hepatitis. Clinical trial number ClinicalTrials.gov Identifier NCT05062967 IMPACT AND IMPLICATIONS While rat hepatitis E virus (ratHEV) is a newly emerging zoonotic virus worldwide, the results of the present study indicate that the molecular diagnosis methods for this virus may be inappropriate. After establishing a proper molecular diagnostic algorithm using available assays, we demonstrated that ratHEV is an emerging and underdiagnosed aetiological agent of acute hepatitis of unknown origin. The results also expand the knowledge of the diversity of ratHEV strains capable of infecting humans in Europe. These findings strongly suggest that ratHEV should be monitored and included in the differential diagnosis of acute hepatitis. |
Value of non-invasive test dynamics in guiding HCC surveillance decisions after HCV cure in patients with cirrhosis. The dynamics of NITs following SVR do not identify cirrhotic patients who could be safely excluded from surveillance programmes. NIT current value is more informative than slope which would necessitate to regularly re-assess HCC risk to design individualized surveillance strategies. Impact and implications It has been postulated that that monitoring noninvasive tests (NIT) dynamics following HCV cure may inform on HCC residual risk in patients with cirrhosis, and may allow for the discontinuation of surveillance in certain patient subsets. We analyzed data from over 3,000 patients and found that while al NITs improved in cirrhotic patients who did not develop HCC, those who eventually developed liver cancer showed more contrasted changes in these tests. Specifically, the current values of tests like Fib4 and APRI were linked to an increased risk of HCC. while their slopes did not provide additional useful information, suggesting that dedicated prospective studies are warranted to define how repeated measurement of NIT could be combined with other variables into HCC risk stratification algorithms. Until then, HCC surveillance should be maintained in al patients with cirrhosis following HCV eradication, even in case of decreased NIT. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Aliment Pharmacol Ther |
|---|
| Clin Gastroenterol Hepatol |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
Vasomics of the liver. Despite this, vasomics is yet to be widely recognised. Therefore, we furnished a comprehensive definition of vasomics providing a classification of existing hepatic vascular phenotypes into the following categories: anatomical, biomechanical, biochemical, pathophysiological and composite. |
| J Hepatol |
Integrative Metabolism in MASLD and MASH: Pathophysiology and Emerging Mechanisms. It highlights the contributions of white adipose tissue insulin resistance and impaired mitochondrial dynamics to hepatic lipid accumulation. Further understanding how the interplay between substrate flux from the gastro-intestinal tract integrates with adipose tissue and intersects with structural and functional alterations to liver mitochondria will be important to identify novel therapeutic targets and advance the treatment of MASLD and MASH. |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Clin Gastroenterol Hepatol |
| Endoscopy |
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| Hepatology |
| J Hepatol |
Letters to the editors and authors’ replies
| Aliment Pharmacol Ther |
|---|
| Gastroenterology |
| Gastrointest Endosc |
| Gut |
| J Hepatol |